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Life 98 REPORT 
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Report LIFE 98

Dissemination activities and deliverables

Laboratory of Andrology

Articles in peer reviewed international journals

  1. Dhooge W, Eertmans F and Comhaire F, Estrogen receptor based in vitro assays for the evaluation of endocrine disrupters. Folia Histochemica et Cytobiologica 39 Suppl 2 (2001) 38-39.
  2. Dhooge W, Stuyvaert S, Kaufman JM, Koppen G, Nelen V, Schoeters G, van Larebeke N, Comhaire F, Observations as to male fertility in the Flemish Environment and Health Studies. Folia Histochemica et Cytobiologica 39 Suppl 2 (2001) 44-45.
  3. Depuydt CE, Mahmoud AM, Dhooge WS, Schoonjans FA, Comhaire FH, Aspects of hormonal regulation of inhibin B secretion by immature rat Sertoli cells in vitro, and its possible use as a bioassay for estrogen detection. J Andrology 20(1) (1999) 54-62.

Articles in international peer reviewed scientific journals not comprised in former section

  1. Comhaire F, Depuydt CE, Mahmoud A, Christophe A, Dhooge W, Schoonjans F, Stratégies de prévention des dommages aux fonctions reproductives masculines dus à l’environnement. Reproduction Humaine et Hormones, 2000; 13: 163-167.
  2. Comhaire F, Dhooge W, Mahmoud A, Depuydt C, Les substances affectant l’équilibre hormonal et la reproduction humaine. Reproduction Humaine et Hormones, 2000; 13: 157-162.

Articles in national peer reviewed scientific journals not comprised in former sections

  1. Comhaire F, Dhooge W, Mahmoud A, Kiss P, Vanhoorne M, Hormoonontregelaars. Zal milieuverontreiniging de menselijke vruchtbaarheid doen uitdoven? Tijdschrift voor Geneeskunde 57(21) (2001) 1469-1474.
  2. Comhaire F, Zalata A, Mahmoud A, Depuydt C, Dhooge W, Christophe C, De rol van reactieve zuurstofspecies en antioxidantia in mannelijke infertiliteit. Tijdschrift voor Geneeskunde 56(6) (2000) 433-437.
  3. Comhaire F, Dhooge W, Depuydt C, Mahmoud A, The role of hormone disrupters in the pathogenesis of male infertility. Newsletter of the Pan Arab Soc of Androl Sci. January 2000.
  4. Comhaire FH, Dhooge W, Mahmoud A, Depuydt C, Een strategie voor de preventie van mannelijke infertiliteit. Verhandelingen van de Koninklijke Academie voor Geneeskunde van België, LXI (3) (1999) 441-455.

Articles in journals not comprised in former sections

  1. Comhaire F, Dhooge W, Mahmoud A, Hormoonontregelaars en hun effect op de mannelijke vruchtbaarheid. Bijblijven 18(1) (2002) 75-81.
  2. Vandenbergh G, Janssen C, De Coen W, Dhooge W, Comhaire F, Distribution and effects of environmental endocrine disrupters in Belgium. Water (2000).
  3. Dhooge W, D'haese I, Versonnen B, Schellekens P, Comhaire F, Verstraete W, Janssen C, Pseudo-hormonen: vruchtbaarheid in gevaar? In Mens: three monthly journal on environment 1999.
  4. Comhaire F, Dhooge W, Mahmoud A, Depuydt C, Les substances affectant l'équilibre hormonal et la reproduction humaine. Santé conjugée 9 (1999) 31-34.

Articles in proceedings of scientific congresses not comprised in former sections

  1. Dhooge W, Eertmans F and Comhaire F. Estrogen receptor based in vitro assays for the evaluation of endocrine disrupters. NATO Advanced Research Workshop: Endocrine disrupters and carcinogenic risk assessment. Nato publications.
  2. Dhooge W, Stuyvaert S, Kaufman JM, Koppen G, Nelen V, Schoeters G, van Larebeke N, Comhaire F. Observations as to male fertility in the Flemish Environment and Health Studies. NATO Advanced Research Workshop: Endocrine disrupters and carcinogenic risk assessment. Nato publications.
  3. I. D’Haese, R.G. Kozak, A. Huysmans, V. Van Malderen, W. Dhooge, M. Weemaes, W. Verstraete; Pharmaceuticals in the Environment: Focus on the estrogen 17alpha-ethinylestradiol. KVIV publications 2000.
  4. Dhooge W, De Coen W, Tanghe T, Verstraete W, Janssen Cand Comhaire FH, Monitoring endocrine toxicity of environmental samples using bioassay directed fractionation procedures. Med. Fac. Landbouw Univ. Gent 64/5a (1999) 59-65.

Abstracts

  1. Comhaire F, Dhooge W, Eertmans F. Environmental Hazards to Male Reproductive Potential. 20th world congress of Dermatology, Paris July 2002, abstract WK0576, abstract book p 1S117.
  2. Dhooge W, Eertmans F and Comhaire F. Estrogen receptor based in vitro assays for the evaluation of endocrine disrupters. NATO Advanced Research Workshop: Endocrine disrupters and carcinogenic risk assessment. Bialystok, Poland, May 2001.
  3. Dhooge W.S, Depuydt C.E, Versonnen B.J, Mahmoud A.M, Comhaire F.H. The Influence of Endocrine Disruptors on the Secretory Function of Cultured Rat Sertoli Cells. Society of Environmental Toxicology and Chemistry, 9th Annual Meeting & Expo, Leipzig, Germany, 1999, abstract 2jPO24, p187.
  4. Dhooge W. and Comhaire F, "Bioassays for the detection of endocrine disrupters in the research on causes of male subfertility". 23rd International LOF-symposium on "Phytoestrogens", Abstract book, 1999.

Lectures

  1. Environmental Hazards to Male Reproductive Potential. 20th world congress of Dermatology, Paris July 2002.
  2. Estrogen receptor based in vitro assays for the evaluation of endocrine disrupters. NATO Advanced Research Workshop: Endocrine disrupters and carcinogenic risk assessment. Bialystok, Poland, May 2001.
  3. Observations as to male fertility in the Flemish Environment and Health Studies. NATO Advanced Research Workshop: Endocrine disrupters and carcinogenic risk assessment. Bialystok, Poland, May 2001.
  4. Flemish Parliament, Hearing 19 february 2001
  5. "The development of a dipstick assay for the detection of estrogenic compounds." Lecture held at the Workshop "New strategies for the monitoring of surface waters quality." KIWA/SVW, 30 June 2000.
  6. "Bio-assay directed fractionation procedures in mixture toxicity evaluation." Lecture held at the Post Graduate Education Endocrinology, 4 November 1999.
  7. "Monitoring endocrine toxicity using bioassay based procedures", Lecture held at the 13th Forum for Applied Biotechnology, 22 September 1999.
  8. "Bioassays for the detection of endocrine disrupters in the research on causes of male subfertility". Lecture held at the 23rd International LOF-Symposium on Phyto-oestrogens, Ghent, 15 January. 1999.
  9. "Strategies for the prevention of (environmental) damage to the reproductive function"; Lecture held at the workshop "Environment and Health", organised by La Fondation Universitaire Luxembourgeoise, de Universitaire Instelling Antwerpen and SANDRINE; Brussels, 14 January, 1999.
  10. "Hormone disrupters in the Environment and Male subfertility"; Lecture held for the "Vereniging voor Fertiliteitsstudie" (Organisation for Fertility Study), Leuven, 20 November 1998.
  11. "Current and future research projects on environmental endocrine disruption"; The Dutch Research Platform on Endocrine Disruption, The Hague, October 1998.

Web page

  1. EMRGent
  2. Life 98 report

Television & radio

A number of interviews on local and (inter)national television and radio stations (VRT, VTM, AVS, German Television, Dutch and Flemish Radio).

Laboratory of Toxicology

Articles in peer reviewed international journals

  1. T. Benijts, J. Vercammen, R. Dams, H.P. Tuan, W. Lambert, and P. Sandra. Stir bar sorptive extraction-thermal desorption-capillary gas chromatography-mass spectrometry applied to the analysis of polychlorinated biphenyls in human sperm. J. Chromatogr. B, 755, 137-142 (2001)
  2. T. Benijts, R. Dams, W. Günther, W. Lambert, and A. De Leenheer. Analysis of estrogenic contaminants in river water using liquid chromatography coupled to ion trap based mass spectrometry. Rapid Commun. Mass Spectrom., 16, 1358-1364 (2002)

Abstracts

  1. T. Benijts, R. Berghmans, E. Bosmans, W. Dhooge, W. Lambert, F. Comhaire, and A.P. De Leenheer. Cloning and expression of human estrogen receptors alpha and beta in human cancer cells. Abstracts of the 4th Workshop on Biosensors and Biological Techniques in Environmental Analysis. Mao, Menorca, Spanje, 01.12.99-03.12.99, Poster P27.
  2. T. Benijts, R. Dams, W. Dhooge, S. Van Calenbergh, W. Lambert, and F. Comhaire. Synthesis and characterization of estradiol labeled liposomes for biosensor development. Abstracts of the workshop "Hormones and Endocrine Disrupters in Food and Water: Possible Impact on Human Health". Copenhagen, Denemarken, 27.05.00 - 30.05.00, Poster 41, p. 84.
  3. T. Benijts, J. Vercammen, W. Lambert, and P. Sandra. Stir bar sorptive extraction (SBSE) applied to the analysis of PPT traces of polychlorinated biphenyls (PCBs) in human sperm. 23th Int. Symposium on Capillary Chromatography, Riva del Garda, Italië, 05.06.00 - 10.06.00, Poster N. 61.
  4. T. Benijts, R. Dams, W. Lambert, and A.P. De Leenheer. Fast analysis of estrogenic compounds by high performance liquid chromatography coupled to ion trap mass spectrometry. Abstract book II of the 25th Intern. Symp. on High Performance Liquid Phase Separations and Related Techniques, Maastricht (Nederland), 17.06.01-22.06.01, p. 246 (Poster P1922).
  5. T. Benijts, R. Dams, W. Lambert, and A.P. De Leenheer. Liquid chromatography coupled to ion trap based mass spectrometry applied in the analysis of estrogenic contaminants. Abstracts of the 11th Nordic Conference on Mass Spectrometry, Loen (Noorwegen), 18.08.01-21.08.01, p. 26 (oral presentation).
  6. T. Benijts, R. Dams, W. Lambert, and A.P. De Leenheer. Applicability of high performance liquid chromatography coupled to ion trap based mass spectrometry in the analysis of endocrine disrupting chemicals. Abstracts of the 7th International symposium on hyphenated techniques in chromatography and hyphenated chromatographic analysers, HTC 7, Brugge, 06.02.02-08.02.02 (oral presentation 18.2).

Laboratory of Hormonology

Articles in peer reviewed international journals

  1. Further evaluation of the biological activity of the unique gonadotropin-releasing hormone peptide in the guinea pig brain”; Gao G.Q., Fraeyman N., Eertmans F., Dhooge W., Kaufman J.-M.; Peptides (in press).

Poster presentations

  1. 17-21 May 2002: Munchen, Germany; 15th international symposium of the journal of Steroid Biochemistry and Molecular Biology; Poster presentation: "A pituitary based in vitro assay for the study of xenoestrogens: I. Method Development"; Eertmans F., Dhooge W., Comhaire F.H and Kaufman J.-M.
  2. 16-19 October 2002: Formia, Italy; Invitox 2002; oral presentation: "Endocrine disruptors: Effects on male fertility and in vitro assays for their evaluation"; Eertmans F., Dhooge W., Comhaire F., Kaufman J.-M.

Laboratory of Microbial Ecology

Articles in peer reviewed international journals

  1. De Rudder, J.; Dhooge, W.; Comhaire F. and Verstraete W. Advanced water treatment with manganese oxide for the removal of 17alpha-ethynylestradiol. Water Research (in progress).
  2. Tanghe T, Dhooge W, Verstraete W, Isolation of a bacterial strain capable to degrade branched nonylphenol. Applied and Environmental Microbiology 65 (2) (1999) 746-751.

Articles in national peer reviewed scientific journals not comprised in former sections

  1. Wouters, R., Lardenoit, R., De Boever, P. and Verstraete, W. (2001). Probiotic removal of herbicides with endocrine disrupting potential from aqueous matrices. Med. Fac. Landbouw. Univ. Gent, 66, 5-13.

Lectures

  1. 10th European Congress on Biotechnology (ECB10), Madrid (8-11/07/01). Lecture: Environmental biotechnology: the ongoing quest.
  2. Workshop des DFG-Graduiertenkollegs AGEESA, Struktur un mikrobieller Abbau endokrin wirksamer Substanzen, RWTH Aachen (16/07/01). Lecture: Monitoring by means of the hER-assay of oestrogens emitted by combustion processes respectively by advanced water treatment processes
  3. Workshop Council of Environmental Quality - Endocrine Team, Hilton Hotel Antwerp (21/05/99). Lecture: Behaviour of endocrine disrupting nonylphenol in the environment
  4. Ausbiotech Conference, Melbourne 2002 (20/08/02) Invited speaker: Environmental Biotechnology for waste treatment

The dissemination activities ie the publications and the lectures at several congresses have contributed to an increased awareness of the need to carefully deal with chemicals which have estrogenic effects. This has resulted in research projects on the detection of the possible endocrine disrupting character of certain emissions and products of pharmaceutical companies. Furthermore, at the Flemish governmental level, there were the invitations to attend to a hearing on the subject (2001) and to write reviews for the MIRA-S and MIRA-T reports (background documents for the Environment and Nature reports of the Flemish Government). With regard to the development of in vitro assays and their applicability for environmental monitoring, there was the demand by the Flemish Environmental Agency (VMM) for the formulation of recommendations towards the use in Flanders of in vitro test systems for the screening of different environmental water matrices.

Furthermore, in the field of water re-use and recycling, the notion that operating water in short cycles should be framed in a HACCP context has been clearly received and several projects on water re-use in Europe are currently carefully examining the ED aspects. The potential positive aspects of probiotic bacteria and their fermentative matrix has attracted the attention of a number of industries. Currently one of these is engaged in a continuation of the research topic ie the use of fermented soy products to equilibrate the estrogenic balance in the gastro-intestinal tract.

 

  
   

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